Best Lion’s Mane Supplement: Our Top 6 Picks for 2024

*Last updated on 23 Jan, 2024*

Choosing the best lion’s mane supplement in 2024 can be pretty challenging with the numerous options available in the market. Lion’s Mane mushroom supplements are top-notch for boosting your brain. They enhance focus, mental alertness, memory, learning, and even creativity. However, we have reviewed several supplement brands and ranked them based on strict criteria. We aim to provide you with safe and effective options that meet high standards in terms of quality, potency, and value.

In this review article, we have taken into account important factors to ensure that the selected lion’s mane supplements are both reliable and beneficial for you.

Best Lion’s Mane Supplements at a Glance

Check out this quick list of the top 6 Lion’s Mane Supplements for 2024.

1. Best Overall: Real Mushrooms Lion’s Mane Cognition Capsules

2. Best For Memory and Nerve Support: Host Defense Lion’s Mane Capsules

3. Best Value: Double Wood Supplements Lion’s Mane Capsules

4. Best for Focus and Immunity: Dr Emil Nutrition Lion’s Mane Capsules

5. Best for Energy and Clarity Support: Genius Mushroom Mixed Mushrooms Capsules

6. Best Powder: Real Mushrooms Lion’s Mane Cognition Extract Powder

6 Best Lion’s Mane Supplements in 2024

People take Lion’s Mane mushroom supplements to enhance mental clarity, focus, and overall wellness. Research shows it’s promising for maintaining cognitive function and preventing decline. It’s great for anyone wanting to support a healthy brain and improve cognitive abilities.

We’ve done the research to find you the best lion’s mane supplements. These brands offer top-notch ingredients and maximum health benefits. They’re 3rd party-tested, dual extracted, 100% vegan, with no fillers or additives. We’ve evaluated and compared them for you, so you can easily pick a recommended lion’s mane supplement with confidence. Check out our list and find the perfect option for your needs.

#1 Real Mushrooms Lion’s Mane Capsules (BEST OVERALL)


  • Designed to improve cognitive function
  • Verified >30 beta-glucan level
  • Third-party tested
  • Manufactured in NSF-certified facilities
  • Affordable
  • Crafted exclusively from 100% mushroom fruiting bodies
  • Completely free from grains, mycelium, additives, or fillers
  • Thousands of satisfied customer reviews


  • Unpleasant taste
  • The capsules can be difficult to swallow

In our opinion, Real Mushrooms Lion’s Mane Capsules stands out as the best lion’s mane supplement in 2024. Firstly, they offer exceptional affordability while maintaining excellent product quality. Secondly, they operate from a certified fulfillment center in Nevada, ensuring their lion’s mane supplement comprises solely the hot water extract of the mushroom fruit body, eliminating any fillers, mycelium, or grain. The hot water extraction method is recognized for its efficacy in extracting vital bioactive compounds from the mushroom. Notably, the mushroom’s fruiting body is the most valuable component for health purposes.

Lastly and crucially, Real Mushrooms guarantees a specific 30% beta-glucan content, which specifically targets immune system benefits. This focus on beta-glucans, pivotal bioactive compounds responsible for many health advantages, ensures consistent product effectiveness. This guarantee establishes trust in obtaining a potent supplement with the intended therapeutic effects. Additionally, their commitment to high-quality, sustainable ingredients further enhances the overall value of their lion’s mane supplement.

With 2 capsules per day, their supplement delivers 1000 mg of lion’s mane and 30% beta-glucan.

A one-time purchase of a 120 capsules bottle costs $29.95 ($0.49 per serving), 60 servings.

📢 SPECIAL OFFER: Subscribe for monthly Real Mushrooms delivery, save 15%!

#2 Host Defense – Lion’s Mane Capsules (BEST PERFORMING)

Host defense lion's mane


  • Designed for memory & nerve support
  • Higher Lion’s Mane content per serving
  • Contains polysaccharides
  • Grown in the USA
  • 100% organic and natural


  • Unpleasant taste
  • Contains Grains
  • Slightly pricier

If you’re looking to improve your cognitive functioning, Host Defense Lion’s Mane Capsules are arguably the top lion’s Mane supplement available. Moreover, research indicates that consuming these capsules can enhance focus, concentration, and clarity of thought, making them an ideal choice for those seeking to boost mental performance. The capsules contain beneficial compounds like hericenones and erinacines, which actively support neuroprotection and promote the production of nerve growth factors, resulting in a healthy nervous system.

Furthermore, these capsules exhibit anti-inflammatory and antioxidant properties. This suggests potential effectiveness in treating various chronic illnesses. However, there are some drawbacks to consider. The amount of beta-glucan they contain remains unspecified, and they are slightly pricier. Moreover, their product includes grains and employs mushroom mycelium. Generally, Lion’s Mane mycelium is considered less preferred than the fruiting body for medical health purposes.

It’s worth noting, though, that this product has gained the trust of over 12,354 satisfied customers and holds an impressive 4.6-star rating on Amazon. So, if you’re aiming to enhance your cognitive abilities, these capsules might be worth a try.

Per serving, this supplement includes 1500mg of organic Lion’s Mane mushroom and 550mg of polysaccharides.

A one-time purchase of a 120 capsules bottle costs $44.98($0.74 per serving), 60 servings.

#3 Double Wood Supplements – Lion’s Mane Mushroom Capsules (BEST VALUE)

double wood lion's mane


  • Supports neurogenesis and brain cell growth
  • Supports mood and immune system
  • Manufactured and grown in the USA
  • Cost-effective
  • Uses the entire fruiting body


  • Contain Grains
  • Take longer to enjoy its effect

If you’re searching for the best lion’s mane supplement capsules to support your immune system, we highly recommend Double Wood Supplements – Lion’s Mane Mushroom Capsules. Firstly, their mushrooms are crafted with certified organic ingredients, offering precisely dosed 500mg extract per capsule for maximum value. Secondly, what sets their lion’s mane capsules apart is the added benefits they provide. They include Bioperine, which enhances absorption in the body, along with other antioxidants that promote optimal health.

Lastly, with Double Wood Supplements, you can trust that you’re getting effective and safe lion’s mane supplements, providing you with peace of mind. Overall, Double Wood Supplements’ Lion’s Mane Mushroom Capsules offer exceptional quality and value.

This supplement per serving contains 1000mg of organic Lion’s Mane mushroom

A one-time purchase of a 120-capsule bottle costs $19.95 ($0.34 per serving), 60 servings.

#4 Dr. Emil Nutrition – Organic Lion’s Mane Mushroom

Dr Emil lion's mane


  • Supports cognitive performance
  • Reduces inflammation & improves gut health
  • Highest Lion’s Mane content per serving in the market
  • Gluten-free, Non-GMO, and 100 percent certified organic lions mane extract


  • Smell of the capsules
  • Slightly pricier

Experience the incredible benefits of Dr. Emil Nutrition’s Organic Lion’s Mane Mushroom Supplement. This supplement is a game-changer for those seeking improvements in cardiovascular health, digestion, brain function, and immunity. It’s worth noting that it’s made from whole, organic mushrooms, ensuring top-quality nutrients. Additionally, it’s infused with natural ingredients, making it a delightful daily supplement to enjoy.

Furthermore, this extraordinary supplement features the highest amount of pure 100% Lion’s Mane extract powder on the market. It is sourced from meticulously selected mushrooms grown in the USA. With that in mind, we wholeheartedly recommend giving this supplement a try. Its positive impact on our well-being has been noticeable, and we firmly believe it can do the same for you.

This supplement per serving contains 2100mg of organic Lion’s Mane mushroom and 10mg of black pepper fruit extract (Bioperine).

A one-time purchase of a 90-capsule bottle costs $22.95 ($0.78 per serving), 30 servings.

#5 Genius Mushroom – Lion’s Mane, Cordyceps, and Reishi

Genius Mushroom


  • Combines 3 medicinal mushroom extracts
  • Designed for Natural Energy, Memory & Liver Support
  • Immune & brain booster
  • Organic ingredients
  • Manufactured in a GMP Certified facility


  • Unknown level of Beta-Glucans
  • Unpleasant taste
  • One serving requires you to take three capsules

If you’re seeking to give your immune system a boost, look into Genius Mushroom. Their formulas contain three powerful natural substances: lion’s mane, cordyceps, and reishi. Lion’s mane primarily focuses on brain health, nerve regeneration, and cognitive enhancement. Cordyceps and reishi contribute to boosting energy, improving stamina, and supporting respiratory health, while also promoting relaxation.

Additionally, they source organic lion’s mane (fruit body), cordyceps (Mycelium), and reishi mushrooms (fruit body), all cultivated in the USA. Importantly, they avoid using any carriers, fillers, or artificial flavors in their products. Their manufacturing takes place in a GMP-certified facility. It’s worth noting that the exact amount of beta-glucan is undisclosed, and there’s no information available about third-party testing.

So, if you’re interested in experiencing the benefits of three medicinal mushrooms in one package, this could be an excellent choice to consider. On Amazon, they’ve amassed an impressive 34,204 ratings with an average score of 4.3, which speaks well of their product’s reputation and quality.

Each serving of these capsules includes 500mg of Organic Lion’s Mane mushroom, 500mg of Cordyceps, and 500mg of Reishi.

A one-time purchase of a 90-capsule bottle costs $21.95 ($0.72 per serving), 30 servings.

#6 Real Mushrooms – Organic Lions Mane Extract Powder (BEST POWDER)

Real Mushroom Lion's mane powder with white background


  • Support brain and immune health actively
  • Actively aid digestion and enhance mood
  • Easy to take
  • Affordable
  • Actively measure beta-glucan levels
  • Certify as 100% USDA organic mushroom extract
  • Enhance absorption rates quickly
  • Do not contain grains, mycelium, additives, or fillers
  • Thousands of positive customer reviews
  • The powders are made from 100% mushroom fruiting bodies 


  • Taste bitter

If you’re not a fan of capsules, you might want to give their organic extract powder a try. This supplement has been proven to offer various cognitive benefits, including reducing inflammation and enhancing short-term memory, focus, concentration, and mental clarity. Additionally, it supports nerve health and provides a mental energy boost when you’re feeling fatigued or stressed.

When it comes to choosing the format, it’s all about personal preference. With the powder, you can simply mix it with warm water or add it to your tea, coffee, smoothies, soup, or even baked treats. This allows you to enjoy the advantages of lion’s mane in your daily routine with ease.

This powder supplement per serving contains 1000mg of organic Lion’s Mane mushroom and 300mg of Beta-glucans.

A one-time purchase of a 60g (pack of 1) costs $29.95 ($0.49 per serving), 60 servings.

📢 SPECIAL OFFER: Subscribe for monthly Real Mushrooms delivery, save 15%!

Comparison of The Top 6 Best Lion’s Mane Supplements

BrandServing SizeLion’s Mane ContentPrice (per serving)Servings
Real Mushrooms Capsules2 capsules1000 mg$0.4960
Host Defense2 capsules1500g$0.7460
Double Wood Supplements2 capsules1000 mg$0.3460
Dr. Emil Nutrition3 capsules1200 mg$0.7830
Genius Mushroom3 capsules500 mg$0.7230
Real Mushrooms Powder1 g/serving1000 mg$0.4960

What is Lion’s Mane?

Lion’s mane (Hericium erinaceus) is a medicinal mushroom that you can find in North America, Europe, and Asia. Its name comes from the shaggy, white appearance resembling a lion’s mane. As a supplement in the nootropic category, it has gained popularity for its potential to enhance cognitive function.

How Does It Work

The neurotrophic properties of lion’s mane are attributed to bioactive compounds called hericenones and erinacines. These compounds have been studied and shown to possess neuroprotective and anti-inflammatory effects. They are known to stimulate the production of nerve growth factor (NGF), a protein crucial for brain cell development and survival.

Lion’s mane also contains beta-glucans, a type of polysaccharide that is believed to stimulate the immune system. Beta-glucans are currently being researched as a potential treatment for cancer.

Clinical studies suggest that an effective dosage of lion’s mane ranges from 250 to 3000 milligrams per day.

Benefits of Lion’s Mane Supplements

Delve deeper into the incredible advantages of Lion’s Mane mushrooms and their profound impact on well-being. Lion’s Mane is known to contain a variety of bioactive substances that can profoundly influence our bodies, particularly our brain, heart, and gut. Extensive research has revealed their anti-inflammatory, antioxidant, and immunostimulating properties, which benefit cells, animals, and humans alike. By embracing Lion’s Mane as a part of your wellness routine, you may unlock a plethora of advantages that promote overall health and vitality.

Protecting the Brain

One of the most remarkable aspects of Lion’s Mane is its ability to prevent brain injury and safeguard cognitive function. Scientific studies have shown promising results, suggesting that Lion’s Mane may contribute to the prevention and treatment of various neurological conditions. Researchers have explored its potential protective effects against dementia, offering hope for those seeking ways to support long-term brain health[1].

Soothing Anxiety and Depression

Anxiety and depression can be debilitating conditions that hinder our daily lives. However, Lion’s Mane mushrooms may offer a glimmer of hope for individuals struggling with mild symptoms. Emerging evidence suggests that the bioactive compounds found in Lion’s Mane could alleviate anxiety and depression, potentially improving overall mental well-being. Incorporating this natural remedy into your self-care routine may provide you with the support you need to navigate life’s challenges with a renewed sense of calm[2].

Boosting Immunity

Maintaining a robust immune system is vital for overall health and vitality. Lion’s Mane mushrooms have shown promising immunostimulating properties, enhancing the body’s defense mechanisms against infections and diseases. By consuming Lion’s Mane regularly, you can potentially strengthen your immune system and improve your body’s ability to fight off harmful pathogens[3].

Nurturing Your Gut

A healthy gut is the cornerstone of overall well-being. Lion’s Mane mushrooms possess the remarkable ability to promote the growth of beneficial bacteria in the gut. By fostering a harmonious microbiome, Lion’s Mane contributes to optimal digestive function and supports overall gut health. Including this magnificent mushroom in your diet can potentially restore balance to your gastrointestinal system, enhancing nutrient absorption and overall digestive well-being[4].

Precautions & Side Effects

Lion’s mane mushroom is generally considered safe for most people to consume. However, it’s important to be aware that like many supplements, lion’s mane mushroom supplements can have potential side effects. These side effects may include nausea, stomach discomfort, and skin irritation in the form of a rash.

If you’re interested in natural supplements for brain health, lion’s mane mushrooms offer a promising avenue to explore. However, it’s crucial to approach their use with caution. It’s always a good idea to consult with your healthcare provider before incorporating lion’s mane supplements into your routine. They can provide personalized guidance based on your specific health needs.

It’s worth noting that while lion’s mane mushrooms hold potential, more research is needed to fully understand their effects on human health and cognition. Well-designed clinical trials can help establish a clearer picture of the benefits and risks associated with lion’s mane supplementation.

Other Medicinal Mushrooms and Their Benefits

  • Reishi mushroom — also known as the “mushroom of immortality,” has several uses in Eastern medicine. Eastern medicine practitioners believe that it can lower cholesterol, increase strength and stamina, boost the immune system, and treat lower urinary tract symptoms in males.
  • Chaga mushroom — a fungus that grows on birch trees in cold climates. People typically steep it in hot water and consume it as tea. It is believed to boost the immune system, reduce inflammation, and support liver health.
  • Cordyceps — a fungus found worldwide. It is parasitic and infects various insects to produce its fruiting body, which is edible. It is thought to have anti-aging and anti-fatigue properties.
  • Turkey tail mushroom — a fungus that grows on dead logs all around the world. It gets its name from its shape and color, resembling turkey tail feathers. Traditional Chinese medicine uses it to treat pulmonary diseases, and it is also being studied for its potential as a cancer treatment.
  • Maitake mushroom — a nutrient-rich fungus used in traditional Asian medicine. It is believed to help manage diabetes, lower cholesterol levels, reduce high blood pressure, and boost the immune system.
  • Shiitake mushroom — an edible mushroom native to East Asia and commonly included in food dishes. It contains a sugar molecule called lentinan, which is believed to offer several health benefits. Although studies have explored its potential to lower high cholesterol and treat infections, clinical data supporting these uses are lacking.

How to Choose The Right Lion’s Mane Supplement For You

When looking at our list of the best lion’s mane supplements, you’ll notice that these products typically contain a blend of active compounds rather than just lion’s mane alone. So, you need to familiarize yourself with the formula to check if you have any allergies or intolerances to the ingredients. Moreover, make sure to cross-check the ingredients list to see if there could be any interactions with your prescription medication, in case you’re taking any. To address these concerns, it’s always helpful to consult with a qualified health professional. They can provide guidance tailored to your specific needs.

How We Rank The Best Lion’s Mane Supplements

To create this roundup of the best lion’s mane supplements, we considered various factors. These factors include examining the product’s formula, assessing the brand’s reputation, checking for third-party testing, evaluating the price per serving, and considering consumer reviews. By considering these aspects, we aimed to provide you with a helpful and well-rounded selection of lion’s mane supplements to choose from.


Which specific raw materials does the product utilize, and what scientifically proven benefits do they offer? Furthermore, can you provide information on the form of these materials? For example, if the product contains a micronutrient, is it in a bioavailable form of the vitamin/mineral?

Extraction Method

What are the advanced extraction techniques used in obtaining lion’s mane extract for supplements, such as hot water extraction or dual extraction? Does the mushroom powder solely consist of 100% mushrooms derived from fruiting bodies, rather than mycelium cultivated on grain like many other brands? 

Dosage and Concentration

What is the recommended frequency for optimal results when using the product? How does the brand’s recommended dosage compare to clinically-backed dosage recommendations for its intended purpose?


Where is the product manufactured and what is the production process like? Does the brand use proprietary blends instead of providing a detailed list of ingredients? Is the product manufactured in a cGMP facility that follows quality standards? Additionally, do they consistently use proprietary blends instead of disclosing the exact composition of the product? Do they conduct regular annual audits to ensure adherence to best practices?

Additional Ingredients

Are there additional ingredients included in the product formulation? Does the product contain any grains, additives, or fillers? 


What testing has been conducted on the product? Has it undergone verification by a reputable third-party source, such as a laboratory or institution?

Customer Reviews and Reputation

What are the customer ratings (pros and cons) for the product on the brand’s website and third-party platforms like Amazon? Does the brand enjoy a positive reputation with satisfied customers and a robust track record of customer reviews?

Price Per Serving

What is the price for a single purchase? How much does each serving cost? How many servings does the product include? Is the higher cost of raw ingredients attributed to the brand or a proprietary blend of ingredients?

Amount of Mushroom Content Per Serving

What is the amount of mushroom content included per serving in the product? Does the product contain any other medicinal compounds? If so, how much of each compound is present in the product?

Brand / Company

How do customers perceive the brand in terms of reputation? Does the brand produce any other comparable products? Is the brand widely recognized and popular? Do health professionals trust or recommend the brand?


Can customers set up subscription orders for the product? Are there any benefits or discounts available with subscription orders?

FAQs For Best Lion’s Mane Supplement

Which Brand is the Best Lion’s Mane?

In our opinion, Real Mushrooms is the best brand for Lion’s Mane. Their Lion’s Mane supplement stands out for its exceptional quality. Customers rave about its effectiveness and reliability. Choose Real Mushrooms for the finest Lion’s Mane experience.

Are Lion’s Mane Supplements Really Worth Taking?

Lion’s mane supplements are worth taking for certain people. They offer numerous potential benefits, such as improved cognitive function and overall brain health. Incorporating Lion’s mane mushrooms into your routine can be a valuable addition to support your overall well-being.

Who Should Not Take Lion’s Mane?

People with mushroom allergies or sensitivities should avoid Lion’s Mane. Pregnant or nursing individuals should consult a healthcare professional before use. If you’re taking medications or have underlying health conditions, seek medical advice as Lion’s Mane may interact with certain drugs or medical conditions. Always prioritize safety and consult a professional when in doubt.

How Do I Choose Lion’s Mane Supplement?

To choose a Lion’s Mane supplement, you should consider factors like the brand’s reputation, product quality, customer reviews, and ingredient transparency. Always look for supplements with high-purity extracts and consider consulting with a healthcare professional to find the best option for you.

Where is the Best Place to Buy Lion’s Mane Supplements?

The best place to buy Lion’s Mane supplements is from reputable retailers or online stores known for quality and transparency. Look for brands with good customer reviews, third-party testing, and clear ingredient information. Always choose reliable sources to ensure you’re getting a safe and effective product.

Summary: Are Lion’s Mane Supplements Worth It?

That’s it – our lineup for the Best Lion’s Mane Supplements in 2023 to boost your brain health and cognition! This medicinal mushroom has long been part of traditional and complementary medicine. While more research is needed to fully understand the health benefits of lion’s mane, there have been positive testimonials suggesting that lion’s mane supplements are indeed worth a try.


1. Hericium erinaceus (Bull.) Pers. Ethanolic Extract with Antioxidant Properties on Scopolamine-Induced Memory Deficits in a Zebrafish Model of Cognitive Impairment. Retrieved from

2. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Retrieved from

3. Polysaccharides from Hericium erinaceus Fruiting Bodies: Structural Characterization, Immunomodulatory Activity and Mechanism. Retrieved from

4. Auxiliary antitumor effects of fungal proteins from Hericium erinaceus by target on the gut microbiota. Retrieved from